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Multalin version 5.4.1
Copyright I.N.R.A. France 1989, 1991, 1994, 1996
Published research using this software should cite
Multiple sequence alignment with hierarchical clustering
F. CORPET, 1988, Nucl. Acids Res., 16 (22), 10881-10890
Symbol comparison table: blosum62
Gap weight: 12
Gap length weight: 2
Consensus levels: high=90% low=50%
Consensus symbols:
! is anyone of IV
$ is anyone of LM
% is anyone of FY
# is anyone of NDQEBZ
MSF: 705 Check: 0 ..
Name: CMC1_HUMAN Len: 705 Check: 3375 Weight: 1.40
Name: CMC2_HUMAN Len: 705 Check: 5689 Weight: 1.40
Name: ARALAR1-1_DROM Len: 705 Check: 8199 Weight: 0.73
Name: ARALAR1-3_DROM Len: 705 Check: 370 Weight: 0.73
Name: ARALAR1-2_DROM Len: 705 Check: 5705 Weight: 0.73
Name: Consensus Len: 705 Check: 5814 Weight: 0.00
//
1 80
CMC1_HUMAN MAVKVQTTKR GDPHELRNIF LQYASTEVDG ERYMTPEDFV QRYLGLYNDP NSNPKIVQLL
CMC2_HUMAN M AAAKVALTKR ADPAELRTIF LKYASIEKNG EFFMSPNDFV TRYLNIFGES QPNPKTVELL
ARALAR1-1_ MPLTKS LPNSPSLLKR AGTEKLREVF LKYASIQKNG EHYMTSEDFV RKFLGLFSES AFNDESVRLL
ARALAR1-3_ MPMHIPFPFN WIPTLPVARC -QESPSLLKR AGTEKLREVF LKYASIQKNG EHYMTSEDFV RKFLGLFSES AFNDESVRLL
ARALAR1-2_ MHD KDESPSLLKR AGTEKLREVF LKYASIQKNG EHYMTSEDFV RKFLGLFSES AFNDESVRLL
Consensus .......... .......... .a.kv.ltKR adp.eLR.!F LkYASi#k#G E.%Mtp#DFV .r%Lgl%.#s ..Npk.V.LL
81 160
CMC1_HUMAN AGVADQTKDG LISYQEFLAF ESVLCAPDSM FIVAFQLFDK SGNGEVTFEN VKEIFGQTII HHHIPFNWDC EFIRLHFGHN
CMC2_HUMAN SGVVDQTKDG LISFQEFVAF ESVLCAPDAL FMVAFQLFDK AGKGEVTFED VKQVFGQTTI HQHIPFNWDS EFVQLHFGKE
ARALAR1-1_ ANIADTSKDG LISFSEFQAF EGLLCTPDAL YRTAFQLFDR KGNGTVSYAD FADVVQKTEL HSKIPFSLDG PFIKRYFGDK
ARALAR1-3_ ANIADTSKDG LISFSEFQAF EGLLCTPDAL YRTAFQLFDR KGNGTVSYAD FADVVQKTEL HSKIPFSLDG PFIKRYFGDK
ARALAR1-2_ ANIADTSKDG LISFSEFQAF EGLLCTPDAL YRTAFQLFDR KGNGTVSYAD FADVVQKTEL HSKIPFSLDG PFIKRYFGDK
Consensus ag!aDqtKDG LIS%qEF.AF EsvLCaPDa$ %.vAFQLFDk .GnGeVt%e# vk#!fgqT.i H.hIPFnwD. eF!.lhFG..
161 240
CMC1_HUMAN RKKHLNYTEF TQFLQELQLE HARQAFALKD KSKSGMISGL DFSDIMVTIR SHMLTPFVEE NLVSAAGGSI SHQVSFSYFN
CMC2_HUMAN RKRHLTYAEF TQFLLEIQLE HAKQAFVQRD NARTGRVTAI DFRDIMVTIR PHVLTPFVEE CLVAAAGGTT SHQVSFSYFN
ARALAR1-1_ KQRLINYAEF TQLLHDFHEE HAMEAFRSKD PAGTGFISPL DFQDIIVNVK RHLLTPGVRD NLVSVTEG-- -HKVSFPYFI
ARALAR1-3_ KQRLINYAEF TQLLHDFHEE HAMEAFRSKD PAGTGFISPL DFQDIIVNVK RHLLTPGVRD NLVSVTEG-- -HKVSFPYFI
ARALAR1-2_ KQRLINYAEF TQLLHDFHEE HAMEAFRSKD PAGTGFISPL DFQDIIVNVK RHLLTPGVRD NLVSVTEG-- -HKVSFPYFI
Consensus rkrhlnYaEF TQfL.#.qlE HA.#AF..kD .a.tG.!s.l DF.DImVt!r .H.LTPfVe# nLVsaagG.. sHqVSFsYFn
241 320
CMC1_HUMAN AFNSLLNNME LVRKIYSTLA GTRKDVEVTK EEFAQSAIRY GQVTPLEIDI LYQLADLYNA SGRLTLADIE RIAPLAEGA-
CMC2_HUMAN GFNSLLNNME LIRKIYSTLA GTRKDVEVTK EEFVLAAQKF GQVTPMEVDI LFQLADLYEP RGRMTLADIE RIAPLEEGT-
ARALAR1-1_ AFTSLLNNME LIKQVYLHAT EGSRTDMITK DQILLAAQTM SQITPLEIDI LFHLAGAVHQ AGRIDYSDLS NIAPEHYTKH
ARALAR1-3_ AFTSLLNNME LIKQVYLHAT EGSRTDMITK DQILLAAQTM SQITPLEIDI LFHLAGAVHQ AGRIDYSDLS NIAPEHYTKH
ARALAR1-2_ AFTSLLNNME LIKQVYLHAT EGSRTDMITK DQILLAAQTM SQITPLEIDI LFHLAGAVHQ AGRIDYSDLS NIAPEHYTKH
Consensus aFnSLLNNME L!rk!Ystla gtrkdve!TK ##f.laAq.. gQ!TP$E!DI L%qLAdly.. .GR.tlaDie rIAPl.eg..
321 400
CMC1_HUMAN LPYNLAELQR QQSPG-LGRP IWLQIAESAY RFTLGSVAGA VGATAVYPID LVKTRMQNQR GSGSVVGELM YKNSFDCFKK
CMC2_HUMAN LPFNLAEAQR QKASGDSARP VLLQVAESAY RFGLGSVAGA VGATAVYPID LVKTRMQNQR STGSFVGELM YKNSFDCFKK
ARALAR1-1_ MTHRLAEIKA VESPAD--RS AFIQVLESSY RFTLGSFAGA VGATVVYPID LVKTRMQNQR A-GSYIGEVA YRNSWDCFKK
ARALAR1-3_ MTHRLAEIKA VESPAD--RS AFIQVLESSY RFTLGSFAGA VGATVVYPID LVKTRMQNQR A-GSYIGEVA YRNSWDCFKK
ARALAR1-2_ MTHRLAEIKA VESPAD--RS AFIQVLESSY RFTLGSFAGA VGATVVYPID LVKTRMQNQR A-GSYIGEVA YRNSWDCFKK
Consensus $p.nLAE.qr q.spgd..Rp ..lQ!aESaY RFtLGSvAGA VGATaVYPID LVKTRMQNQR ..GS.!GElm YkNSfDCFKK
401 480
CMC1_HUMAN VLRYEGFFGL YRGLIPQLIG VAPEKAIKLT VNDFVRDKFT RRDGSVPLPA EVLAGGCAGG SQVIFTNPLE IVKIRLQVAG
CMC2_HUMAN VLRYEGFFGL YRGLLPQLLG VAPEKAIKLT VNDFVRDKFM HKDGSVPLAA EILAGGCAGG SQVIFTNPLE IVKIRLQVAG
ARALAR1-1_ VVRHEGFMGL YRGLLPQLMG VAPEKAIKLT VNDLVRDKLT DKKGNIPTWA EVLAGGCAGA SQVVFTNPLE IVKIRLQVAG
ARALAR1-3_ VVRHEGFMGL YRGLLPQLMG VAPEKAIKLT VNDLVRDKLT DKKGNIPTWA EVLAGGCAGA SQVVFTNPLE IVKIRLQVAG
ARALAR1-2_ VVRHEGFMGL YRGLLPQLMG VAPEKAIKLT VNDLVRDKLT DKKGNIPTWA EVLAGGCAGA SQVVFTNPLE IVKIRLQVAG
Consensus VlRyEGFfGL YRGLlPQL.G VAPEKAIKLT VNDfVRDKft .kdGs!Pl.A E!LAGGCAGg SQV!FTNPLE IVKIRLQVAG
481 560
CMC1_HUMAN EITTGPRVSA LNVLRDLGIF GLYKGAKACF LRDIPFSAIY FPVYAHCKLL LADENGHVGG LNLLAAGAMA GVPAASLVTP
CMC2_HUMAN EITTGPRVSA LSVVRDLGFF GIYKGAKACF LRDIPFSAIY FPCYAHVKAS FANEDGQVSP GSLLLAGAIA GMPAASLVTP
ARALAR1-1_ EIASGSKIRA WSVVRELGLF GLYKGARACL LRDVPFSAIY FPTYAHTKAM MADKDGYNHP LTLLAAGAIA GVPAASLVTP
ARALAR1-3_ EIASGSKIRA WSVVRELGLF GLYKGARACL LRDVPFSAIY FPTYAHTKAM MADKDGYNHP LTLLAAGAIA GVPAASLVTP
ARALAR1-2_ EIASGSKIRA WSVVRELGLF GLYKGARACL LRDVPFSAIY FPTYAHTKAM MADKDGYNHP LTLLAAGAIA GVPAASLVTP
Consensus EIttGpr!sA lsVvR#LG.F GlYKGAkACf LRD!PFSAIY FP.YAH.Ka. .A#e#G.v.p l.LLaAGAiA GvPAASLVTP
561 640
CMC1_HUMAN ADVIKTRLQV AARAGQTTYS GVIDCFRKIL REEGPSAFWK GTAARVFRSS PQFGVTLAHY EVLQRWFYID FGGLKPAGSE
CMC2_HUMAN ADVIKTRLQV AARAGQTTYS GVIDCFRKIL REEGPKALWK GAGARVFRSS PQFGVTLLTY ELLQRWFYID FGGVKPMGSE
ARALAR1-1_ ADVIKTRLQV VARSGQTTYT GVWDATKKIM AEEGPRAFWK GTAARVFRSS PQFGVTLVTY ELLQRLFYVD FGGTQPKGSE
ARALAR1-3_ ADVIKTRLQV VARSGQTTYT GVWDATKKIM AEEGPRAFWK GTAARVFRSS PQFGVTLVTY ELLQRLFYVD FGGTQPKGSE
ARALAR1-2_ ADVIKTRLQV VARSGQTTYT GVWDATKKIM AEEGPRAFWK GTAARVFRSS PQFGVTLVTY ELLQRLFYVD FGGTQPKGSE
Consensus ADVIKTRLQV aARaGQTTYs GViDcfrKI$ rEEGP.AfWK GtaARVFRSS PQFGVTL.tY ElLQRwFY!D FGG.kP.GSE
641 705
CMC1_HUMAN P----TP-KS RIADLPPANP DHIGGYRLAT ATFAGIENKF GLYLPKFKSP SVAVVQPKAA VAATQ
CMC2_HUMAN P----VP-KS RI-NLPAPNP DHVGGYKLAV ATFAGIENKF GLYLPLFK-P SVSTSKAIGG GP
ARALAR1-1_ AHKITTPLEQ AAASVTTENV DHIGGYRAAV PLLAGVESKF GLYLPRFGRG VTAASPSTAT GS
ARALAR1-3_ AHKITTPLEQ AAASVTTENV DHIGGYRAAV PLLAGVESKF GLYLPRFGRG VTAASPSTAT GS
ARALAR1-2_ AHKITTPLEQ AAASVTTENV DHIGGYRAAV PLLAGVESKF GLYLPRFGRG VTAASPSTAT GS
Consensus p....tP.ks ria.lp..Np DH!GGYrlAv atfAG!EnKF GLYLP.Fk.p sva.s...a. g....